Issue with sending Mailing

I am getting below errror while sending any mail , this error was not coming before. Suddenly it started . I have checked everything and not able to rectify it.

Oct 20 10:02:06 localhost sm-mta[8590]: 39K4W6oX008590: from=<>, size=930, class=0, nrcpts=1, msgid=<NepXRuWYyD0ZtOIf34Ez4SbLNAXNTh4Sz4VVePNbvtQ@192.168.37.207>, proto=ESMTP, daemon=MTA-v4, relay=localhost [127.0.0.1]
Oct 20 10:02:07 localhost sm-mta[8592]: 39K4W6oX008590: to=<This email address is being protected from spambots. You need JavaScript enabled to view it.>, delay=00:00:01, xdelay=00:00:01, mailer=esmtp, pri=120930, relay=sandesh.cdot.in. [196.1.105.47], dsn=5.7.1, stat=Service unavailable
Oct 20 10:02:07 localhost sm-mta[8592]: 39K4W6oX008590: to=postmaster, delay=00:00:01, mailer=local, pri=120930, dsn=5.1.1, stat=User unknown
Oct 20 10:02:07 localhost sm-mta[8592]: 39K4W6oX008590: 39K4W7oX008592: postmaster notify: User unknown
Oct 20 10:02:07 localhost sm-mta[8592]: 39K4W7oX008592: to=MAILER-DAEMON, delay=00:00:00, mailer=local, pri=0, dsn=5.1.1, stat=User unknown
Oct 20 10:02:07 localhost sm-mta[8592]: 39K4W7oX008592: to=postmaster, delay=00:00:00, mailer=local, pri=0, dsn=5.1.1, stat=User unknown
Oct 20 10:02:07 localhost sm-mta[8592]: 39K4W7oX008592: 39K4W7oY008592: return to sender: User unknown
Oct 20 10:02:07 localhost sm-mta[8592]: 39K4W7oY008592: to=MAILER-DAEMON, delay=00:00:00, mailer=local, pri=0, dsn=5.1.1, stat=User unknown
Oct 20 10:02:07 localhost sm-mta[8592]: 39K4W7oX008592: Losing ./qf39K4W7oX008592: savemail panic
Oct 20 10:02:07 localhost sm-mta[8592]: 39K4W7oX008592: SYSERR(root): savemail: cannot save rejected email anywhere

Please let me know to resolve the issue.

Thanks,
Naveen

Please let me know the parameters for verification. As of my knowledge, I havent changed any parameters.

Hello Sir,
I have tried that also, still some issue.